This study aimed to better understand how changes in brain activity may be related to cognitive decline in Parkinson’s disease (PD). We hypothesized that reductions in gamma activity are a key mechanism underlying cognitive dysfunction in PD and that interventions to increase gamma activity will improve cognition. One intervention we tested in the lab was repetitive transcranial magnetic stimulation. 

Defining Phenotypes of Movement Disorders: Parkinson’s Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography. (PHENO).

Cognitive Dysfunction In Parkinson’s.

Cognitive Dysfunction in Parkinson’s Disease.

Publications:

“Transcranial Magnetic Stimulation Does Not Improve Mild Cognitive Impairment in Parkinson’s Disease” Buard I., et al (2017).

“Does repetitive transcranial magnetic stimulation (rTMS) affect cognitive function in Parkinson’s disease by modulating high-frequency brain oscillations: A magnetoencephalography (MEG) study.” Buard I., Shattuck J., Kluger B.M. (2016).

“Cortical physiology as a therapeutic target in Parkinson′s disease related dementia and cognitive dysfunction: study protocol for a randomized controlled trial.” Buard I., Martin C.S., Kluger B.M. (2016).